Table 6.
Comparison of covariates in patients with lung adenocarcinomas with different molecular status.
| Variable |
KRAS mutation/ no associated co-mutation (N= 436) |
sEGFR mutation/ no associated co-mutation (N= 174) |
oEGFR mutation/ no associated co-mutation (N= 104) |
ALK rearrangemen/ no associated co-mutation (N= 95) |
KRAS wildtype/ no associated co-mutation (N= 706) |
P |
|---|---|---|---|---|---|---|
| Age (years), median (IQR) | 65 (56 - 70) | 61 (56 - 70) | 63 (56 - 70) | 54.5 (46 - 63) | 64 (56 - 70) | <0.001 |
| White | 390 (94.2) | 124 (79.49) | 78 (81.25) | 79 (92.94) | 595 (88.94) | <0.001 |
| Ever smoker | 403 (92.86) | 75 (43.1) | 42 (40.38) | 41 (43.16) | 528 (75.86) | <0.001 |
| ECOG | ||||||
| 0 | 132 (30.34) | 68 (39.53) | 41 (40.59) | 38 (40.43) | 207 (29.49) | 0.023 |
| 1 | 256 (58.85) | 96 (55.81) | 51 (50.5) | 49 (52.13) | 433 (61.68) | |
| 2 | 47 (10.8) | 8 (4.65) | 9 (8.91) | 7 (7.45) | 62 (8.83) | |
| Surgery history for lung cancer treatment | 221 (52.74) | 52 (31.9) | 49 (51.58) | 45 (48.39) | 354 (52.29) | <0.001 |
| Radiation treatment history for lung cancer | 154 (35.81) | 49 (28.82) | 44 (43.14) | 39 (41.49) | 271 (39.11) | 0.067 |
| Chemotherapy history for lung cancer | 111 (51.15) | 39 (41.49) | 9 (52.94) | 12 (35.29) | 245 (61.56) | <0.001 |
| Targeted therapy given | 33 (8.31) | 151 (88.82) | 70 (70.71) | 65 (69.15) | 21 (3.87) | <0.001 |
Data are presented as number of patients (%) or median (IQR, interquartile range).
P-value is calculated by Kruskal-Wallis test for age, and chi-square test or Fisher’s exact test for categorical variables, where appropriate.