TABLE 2:
Summary of the increases (↑) and decreases (↓) in experimental values in genetically modified mice compared with controls.
| MBP expression | CNPase expression | g-ratio | pMBS pRho kinase | |
|---|---|---|---|---|
| P14 Rnd2 KO | ↓ | ↓ | ↑ | ↑ |
| P28 Rnd2 KO | ↑ | ↑ | ↓ | ↓ |
| P14 Rnd2 Tg | ↑ | ↑ | ↓ | ↓ |
| P28 Rnd2 Tg | ↓ | ↓ | ↑ | ↑ |
| 2 wk after tamoxifen | ↓ | ↓ | ↑ | n. d. |
| 4 wk after tamoxifen | ↑ | ↑ | ↓ | n. d. |
n. d. indicates not determined.