TABLE 2:
LIN-10 and LIN-7 overexpression rescues a PDZ interaction-deficient let-23(sy1) receptor mutant, but not signaling-defective let-23(sy97).
| Genotype | % Vul | % Muv | Avg. # of VPCs induced | n | |
|---|---|---|---|---|---|
| 1 | let-23(sy1) | 92 | 0 | 0.40 | 36 |
| 2 | let-23(sy1); GFP::LIN-10 | 30**** | 10 | 2.72**** | 30 |
| 3 | let-23(sy1); LIN-7::EGFP | 52*** | 0 | 2.08**** | 25 |
| 4 | let-23(sy97) | 95 | 0 | 0.48 | 43 |
| 5 | let-23(sy97); GFP::LIN-10 | 96 | 0 | 0.72 | 25 |
| 6 | let-23(sy97); LIN-7::EGFP | 100 | 0 | 0.25 | 22 |
*** p < 0.001; **** p < 0.0001; Fisher’s exact test (%Muv and %Vul); one-way ANOVA with multiple comparisons (Avg # VPCs induced). Rows 2 and 3 were compared with row 1; rows 5 and 6 were compared with row 4.