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. 2021 Mar 9;6(1):e892. doi: 10.1097/PR9.0000000000000892

Figure 1.

Figure 1.

In the context of a chronic progressive disease such as osteoarthritis, the interactions between macrophages, tissue resident cells, and nociceptors at the level of the joint, DRG, and spinal cord may provide an ever-changing network of signals that are important in perpetuating pain. These signaling molecules include chemokines, cytokines, neurotrophins, and proresolving mediators, among others.