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The D398-R355 pair in human coronaviruses. Predicted destabilizing and stabilizing ΔpKas of R355 and D398 for the five human coronaviruses with available RBD structural information (A). Sequences for the seven human coronavirus are aligned over this region (B), with secondary structure added from 6vsbB, and sequence conservation displayed (ESPript). Locations of R355 and D398 are indicated with purple spheres.
