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. Author manuscript; available in PMC: 2021 May 10.
Published in final edited form as: Biochem Soc Trans. 2020 Dec 18;48(6):2565–2578. doi: 10.1042/BST20200250

Figure 3. Nuclear-encoded mRNA localization to mitochondria and potential regulatory mechanism in changing environmental condition.

Figure 3.

After the export form nuclear pore, nuclear-encoded mitochondrial mRNAs are diffusively localized to mitochondrial surface by binding to mitochondrial protein import machinery, TOM complex. The interaction between mRNA and Protein import machinery are summarized in the right box. Briefly, mRNAs bind mitochondria through a mitochondrial targeting signal in the nascent polypeptide chain. Targeting signal associates with Tom20 and Tom70 with the help of chaperone proteins Hsp70 and Djp1. Pumilio family protein (Puf3 in yeast and CLUH in mammalian cells) directly bind mRNA in a sequence-dependent manner. Association of ribosomes to OM14 and OM45 are also reported.