Table 2.

Change in marker levels between baseline and week 3

Marker	Baseline, median (IQR)	Week 3, median (IQR)	Change, median (IQR)	P value for change
Stroma (cells/megapixel)
CD4	63.9 (29.4–119.9)	102.2 (50.8–199.2)	29.1 (−8.0 to 112.1)	<0.001
CD8	27.8 (17.6–42.0)	52.1 (32.7–80.3)	20.1 (0.0–42.1)	<0.001
CD4/CD8	2.1 (1.1–3.8)	2.3 (1.1–3.1)	0.0 (−1.3 to 0.8)	0.423
T cell	102.3 (50.0–167.8)	168.4 (86.2–270.9)	49.8 (5.3–153.9)	<0.001
CD73	39.9 (25.8–73.3)	51.2 (30.7–100.1)	6.4 (−9.7 to 35.3)	0.015
PD1 in CD4	5.8 (3.1–15.0)	6.1 (2.5–12.2)	−1.0 (−4.5 to 3.3)	0.265
PD1 in CD8	25.5 (11.5–43.4)	31.9 (20.5–50.9)	3.5 (−7.4 to 19.2)	0.019
PDL1	54.0 (15.8–146.4)	68.1 (37.5–149.9)	6.9 (−25.5 to 78.0)	0.279
Tumor (cells/megapixel)
CD4	13.4 (3.9–29.3)	24.9 (11.8–72.8)	10.3 (−4.3 to 48.9)	0.003
CD8	19.0 (6.5–29.4)	35.2 (17.1–74.9)	21.6 (−1.4 to 43.8)	<0.001
CD4/CD8	0.8 (0.3–2.2)	0.8 (0.3–2.0)	0.0 (−0.8 to 0.4)	0.492
T cell	34.7 (13.6–88.5)	85.8 (27.9–143.5)	39.0 (−0.8 to 103.5)	<0.001
CD73	33.1 (18.4–80.0)	43.8 (18.4–74.5)	−1.3 (−25.7 to 22.9)	0.982
PD1 in CD4	11.0 (4.9–22.5)	12.7 (4.2–33.3)	1.8 (−5.6 to 10.9)	0.144
PD1 in CD8	15.6 (5.2–38.0)	29.7 (14.3–44.7)	9.5 (−5.1 to 26.5)	0.001
PDL1	35.0 (14.1–117.1)	72.0 (22.5–194.8)	32.3 (−6.6 to 112.7)	0.003