Table 3.

Five-year RFS and OS rates for patients with individual irAEs and a highest CTCAE grades of 1–2 versus grade 0

	5-year RFS, % (95% CI)			5-year OS, % (95% CI)
	Grades1–2	No AE	P value*	Grades 1–2	No AE	P value*
Rash	52 (47 to 57)	45 (40 to 50)	0.002	75 (71 to 79)	68 (65 to 72)	0.004
Endocrine	54 (47 to 60)	47 (43 to 50)	0.002	79 (73 to 84)	70 (66 to 74)	0.013
Endocrine and rash	54 (49 to 53)	41 (36 to 47)	<0.001	77 (73 to 80)	68 (62 to 73)	<0.001
Diarrhea/colitis	51 (46 to 57)	48 (45 to 51)	0.094	72 (68 to 77)	71 (66 to 75)	0.343

*Based on the log-rank test.

CTCAE, Common Terminology for Adverse Events; irAE, immune-related adverse event; OS, overall survival; RFS, relapse-free survival.