Table 2.

Intracellular proteins of F. tricinctum M6 identified in the presence of Cu(II) in the culture medium.

Sequence ID^a	Sequence name^b	Protein length (AA)^c	Protein weight (kDa)^d
Protein biosynthesis
A0A2H3HCL8	Elongation factor 1-gamma 1	425	47.78
A0A0D2XB67	40 S ribosomal protein S21	87	9.63
A0A0D2XA48	GrpE protein homolog	244	27.43
A0A0D2XWU0	T-complex protein 1 subunit alpha	565	61.32
A0A0D2Y4M4	40 S ribosomal protein S2	257	27.97
A0A2H3HCC0	40 S ribosomal protein S22	130	14.79
A0A0D2Y2F8	40 S ribosomal protein S19	150	16.58
A0A0D2XJG4	60 S ribosomal protein L27a	149	16.79
Oxidation-Reduction Processes
N1RL11	NADH-ubiquinone oxidoreductase 29.9 kDa subunit, mitochondrial	235	26.92
N1RDJ1	L-aminoadipate-semialdehyde dehydrogenase large subunit	1163	129.01
A0A0D2XAA8	Inosine-5′-monophosphate dehydrogenase	532	56.83
A0A0D2YFU9	DAO domain-containing protein	533	57.75
A0A0D2XC02	D-3-phosphoglycerate dehydrogenase 2	473	51.62
S0EP01	Probable LEU2-beta-isopropyl- malate dehydrogenase	1084	118.61
I1S2Z0	PKS_ER domain-containing protein	368	39.83
A0A0D2Y544	UDPglucose 6-dehydrogenase	605	66.18
A0A0J9VP92	Uncharacterized protein FOXG_12068	501	54.50
Degradation proteins
A0A2H3HD18	Vacuolar protease A (Fragment)	429	46.42
A0A0D2Y1V9	26 S protease regulatory subunit 6 A	459	50.92
A0A0D2XML3	E3 ubiquitin-protein ligase	810	91.38
A0A0J9UJ20	26 S proteasome regulatory subunit N7	392	42.69
N1RE30	Cys-Gly metallodipeptidase dug1	460	50.55
W7MDN2	Mitochondrial-processing peptidase subunit alpha	532	57.97
A0A0D2×9D5	26 S protease regulatory subunit 7	440	49.07
I1RFS5	Peptidase alpha subunit	565	61.44
A0A0J9ULK9	F-box domain-containing protein	529	60.77
C7Z9Q6	Predicted protein NECHADRAFT_94534	577	62.78
I1RQ19	Uncharacterized protein FG06152.1	838	91.93
Nucleic acid binding proteins
A0A2H3THI2	Related to TATA-binding protein associated factor 2 N	348	38.23
A0A0J9WA35	BZIP domain-containing protein	212	24.35
Q4HTT2	Histone H2B	137	14.75
K3VN47	Zn(2)-C6 fungal-type domain- containing protein	1024	116.72
C7YIM9	Uncharacterized protein BRD2103	675	74.94
C7YNQ5	Uncharacterized protein NECHADRAFT_60425	604	65.40
A0A0J9V1M3	Uncharacterized protein FOXG_07428	841	94.08
Stress proteins
A0A0C4DHU2	Glutathione reductase	506	54.79
Kinases/Phosphatases
A0A0D2XQI2	3′(2′),5′-bisphosphate nucleotidase	408	43.65
A0A0D2Y8P5	Adenylate kinase	256	28.26
A0A0J9WPA8	Protein phosphatase 2 (Formerly 2 A), regulatory subunit A	514	57.03
Energy metabolism
A0A0D2XEG1	ATP synthase subunit delta, mitochondrial	165	17.70
A0A0D2XAN8	V-type proton ATPase subunit B	511	56.65
A0A0D2XHL0	V-type proton ATPase subunit E	229	25.83
A0A0J9UCJ3	V-type proton ATPase catalytic subunit A	788	85.90
Carbohydrate metabolism
A0A0D2Y1Y2	Fructose-bisphosphate aldolase, class II	360	39.61
A0A0D2XEA1	Triosephosphate isomerase	247	27.06
A0A0D2XGP1	Fumarate hydratase, mitochondrial	529	56.80
A0A0D2×829	Enolase	438	47.28
A0A0D2Y4K0	Glucose-6-phosphate 1-epimerase	313	33.58
Post-translational modifications (PTMs)
A0A0D2YKT2	1,3-beta-glucanosyltransferase	375	41.05
K3VMJ8	Uncharacterized protein FPSE_04909	513	58.50
Other
N1RHH1	Tropomyosin-2	161	18.79
A0A0D2XNF4	Myo-inositol-1-phosphate synthase	541	59.44
A0A0D2XHT9	Phospho-2-dehydro-3- deoxyheptonate aldolase	317	34.11
N1REE8	Rho GDP-dissociation inhibitor	198	22.16
A0A2H3GY22	Reduced viability upon starvation protein 167	434	49.42
A0A0D2×9R5	S-adenosylmethionine synthase	403	44.27
A0A2H3G4L5	ATP phosphoribosyltransferase	325	35.33
A0A0D2XX43	pHdomain-containing protein	834	91.54
A0A0J9WG59	Abhydrolase_3 domain-containing protein	259	28.70
A0A0D2XWU1	Prolyl-tRNA synthetase	553	62.36
S0DLW9	Related to putative sterigmatocystin biosynthesis lipase/esterase STCI	364	40.68
A0A0J9WKR9	Cysteine desulfurase	401	43.75
C7Z6×3	Predicted protein NECHADRAFT_33672	2106	231.18

Accession numbers from UniProtKB/TrEMBL (https://www.uniprot.org) and NCBI (http://www.ncbi.nlm.nih.gov).

^b,c,d

Function annotations were retrieved from NCBInr (http://www.ncbi.nlm.nih.gov) and UniProt (https://www.uniprot.org/).