Table II.
Time Course of Nonpersistence and Insufficient Response
| Time course group | Overall | Chlorthalidone | Hydrochlorothiazide |
|---|---|---|---|
| Nonpersistence, No.a | 35,270 | 857 | 34,413 |
| After single fill | 13,370 (37.9%) | 316 (36.9%) | 13,054 (37.9%) |
| Two fills, but within 180 days | 11,002 (31.2%) | 298 (34.8%) | 10,704 (31.1%) |
| Within 1 y | 10,898 (30.9%) | 243 (28.4%) | 10,655 (31.0%) |
| Inadequate response, No.b | 27,318 | 331 | 26,987 |
| 15–30 d | 1900 (7.0%) | 27 (8.2%) | 1927 (7.1%) |
| 31–90 d | 5529 (20.2%) | 71 (21.5%) | 5458 (20.2%) |
| 91–180 d | 7216 (26.4%) | 81 (24.4%) | 7135 (26.4%) |
| 181–365 d | 12,646 (46.3%) | 152 (45.9%) | 12,494 (46.3%) |
aTest for difference in time course distribution between hydrochlorothiazide and chlorthalidone: χ2=5.7; degrees of freedom (DF)=2; P=.0580. bTest for difference in time course distribution between hydrochlorothiazide and chlorthalidone: χ2=1.31; DF=3; P=.7268.