. 2012 May 14;14(7):467–471. doi: 10.1111/j.1751-7176.2012.00642.x

Table II.

Reviewed Trials of Dietary Supplements in Hypertension

Author, Year	Study Design	Participants, No.^a	Product	Dose	BP Change in Intervention Group, mm Hg		Product Analysis
Author, Year	Study Design	Participants, No.^a	Product	Dose	SBP	DBP	Product Analysis
Singh et al, ¹¹ 1999	DB, PC, RCT	59	CoQ10	60 mg twice daily	16	9	Not noted
Burke et al, ¹² 2001	DB, PC, RCT	80	CoQ10	60 mg twice daily	17.8	2.6	Not noted
Digiesi et al, ¹³ 1994	Open‐label	26	CoQ10	50 mg twice daily	17.8	10	Not noted
Langsjoen et al, ¹⁴ 1994	Open‐label	109	CoQ10	Average dose of 225 mg/d	12	9	Not noted
Prisco et al, ¹⁵ 1998	DB, PC, RCT in parallel	32	Fish oil	Fish oil 2.04 g EPA and 1.4 g DHA	6	5	Not noted
Yosefy et al, ¹⁶ 1999	Two open‐label trials	Nondiabetic: 20  Diabetic: 19	Fish oil	Fish oil 2700 mg EPA and 1800 mg DHA/d divided TID	Nondiabetic: 12.7  Diabetic: 15.7	7.9  7.6	Not noted
Auer et al, ¹⁷ 1990	DB, PC, RCT	47	Garlic powder	200 mg TID	19	9	Not noted
Vorberg and Schneider, ¹⁸ 1990	DB, PC, RCT	40	Garlic powder	900 mg/d	9^b	6.5^b	Not noted
Duffy et al, ²³ 1999	DB, PC, RCT	39	Ascorbic acid	2 g load then 500 mg/d	13	NS	Not noted
Sato et al, ²⁴ 2006	Open‐label	24	Ascorbic acid	200 mg TID	20	NS	Not noted

Abbreviations: CoQ10, coenzyme Q‐10; DBP, diastolic blood pressure; DB, double‐blind; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; NS, no significant change; PC, placebo‐controlled; R, randomized controlled trial; SBP, systolic blood pressure; TID, 3 times a day. ^aOnly included those who completed the investigations. ^bNoted changes in SBP or DBP are from the meta‐analysis.