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. 2021 May 7;9:e11306. doi: 10.7717/peerj.11306

Figure 1. The relationship between HIF-1α and immune checkpoints.

Figure 1

(A) HIF1A expression in various tumors. HIF1A is overexpressed in seven types of tumors of ESCA, GBM, HNSC, LAML, LGG, PAAD and STAD. (B) The protein-proteininteraction (PPI) network constructed by HIF1A, CD274, PDCD1, CTLA4, LAG3, CD47 and HAVCR2 genes. HIF-1α is directly related to PDL1 and CTLA4, according to the analysis of the literature. (C) The correlation between HIF1A and immunotherapy-related target genes in carcinomas. The upper abscissa and left ordinate represent HIF1A and immune checkpoint genes, and the lower abscissa represents Pearson’s correlation coefficient (r). The maximum diameter of circle represents the size of absolute r value in the circle. Blue and red circles with different shades represent different degrees of positive and negative correlation, respectively. (D) The correlation between HIF1A and CD274 expression in PAAD. (E) The correlation between HIF1A and CD274 expression in STAD. (F) The correlation between HIF1A and CD274 expression in GBM. (G) The correlation between HIF1A and CD274 expression in LGG. (H) The correlation between HIF1A and CD274 expression in ESCA. (I) The correlation between HIF1A and CD274 expression in HNSC. The abscissa represents the expression levels of CD274 and the ordinate represents the expression levels of HIF1A. Image credit: (A) GEPIA web at http://gepia.cancer-pku.cn/detail.php. (B) STRING web at https://string-db.org/. (C) Bioinformastics at http://www.bioinformatics.com.cn/. (D–I) TIMER at https://cistrome.shinyapps.io/timer/. Abbreviations: HIF-1α, Hypoxia-inducible factor-1 α; ESCA, Esophageal cancer; GBM, Glioblastomamultiforme; HNSC, Head and neck squamous cell carcinoma; LGG, Lower grade glioma; STAD, Stomachadenocarcinoma; CTLA4, Cytotoxic T-lymphocyte-associated antigen 4; LAG3, Lymphocyte activation gene 3; PDL1, Programmed death-ligand 1; LAML, Acute myeloid leukemia.