Table 1. The regulation of immune checkpoints by hypoxia-associated molecules.

Hypoxia-associated molecules	Immune checkpoints	Impact on immune checkpoints	References
HIF-1α	PDL1	Stimulatory	Lequeux et al. (2019) and Zhou et al. (2019)
HIF-1α	CTLA4, LAG3	Stimulatory	Doedens et al. (2013)
PKM2, PHD3	PDL1	Stimulatory	Palsson-McDermott et al. (2017)
CA9	PDL1	Stimulatory	Giatromanolaki & Harris (2020)
Ado, A2aR, A2bR, cAMP	PD1, CTLA4	Stimulatory	Hatfield et al. (2015)
Ado	PD1	Stimulatory	Allard et al. (2013)
Lactate, GPR81, TAZ, TEAD	PDL1	Stimulatory	Feng et al. (2017)
LDH-A	PDL1	Stimulatory	Seth et al. (2017)
ZEB1	PDL1	Stimulatory	Chen et al. (2014)
SNAIL	PDL1	Stimulatory	Noman et al. (2017)
ZEB1, SNAIL	CD47	Stimulatory	Noman et al. (2018)
cAMP, PKA	PDL1	Inhibitory	Feng et al. (2017)
miR-200	PDL1	Inhibitory	Noman et al. (2017)