Table 1.
Demographics of Discovery cohort
| Total | PRISm | Control | COPD | Missing | p | |
|---|---|---|---|---|---|---|
| No. of participants (%) | 957 | 85 (8.9) | 390 (40.8) | 468 (48.9) | 14 (1.4) | |
| Agea | 68.3 (8.4) | 66.7 (7.3) | 65.9 (8.5) | 70.5 (8.0) | 70.7 (5.8) | <0.0001 |
| Male sex (%) | 490 (51.2) | 31 (36.5) | 184 (47.2) | 268 (57.3) | 7 (50.0) | 0.0002 |
| BMI (%) | 29.1 (6.2) | 32.6 (7.7) | 29.3 (5.6) | 28.2 (6.1) | 27.9 (5.3) | <0.0001 |
| Current smoker (%) | 204 (21.3) | 24 (28.2) | 78 (20.0) | 98 (20.9) | 4 (28.6) | 0.1914 |
| Smoking pack-yearsa | 46.0 (24.9) | 48.6 (24.3) | 36.1 (19.5) | 53.6 (26.2) | 51.7 (22.2) | <0.001 |
| FEV1pp_utaha | 76.6 (26.5) | 70.2 (7.4) | 99.2 (11.5) | 58.9 (23.5) | NA | NA |
| FEV1/FVCa | 0.7 (0.2) | 0.8 (0.0) | 0.8 (0.0) | 0.5 (0.1) | NA | NA |
| Percent emphysemaa | 7.3 (10.2) | 1.6 (2.5) | 2.2 (2.6) | 12.9 (12.2) | 9.2 (11.7) | <0.0001 |
Chi-square tests were used to test for differences between groups in binary variables. One-way ANOVA tests were performed to test for differences between groups in continuous variables.
PRISm, Preserved Ratio Impaired Spirometry23; COPD is defined by GOLD score ≥1; missing, 14 subjects were deemed ineligible for spirometry and thus did not have a defined GOLD status. These subjects were still included in analyses with other COPD phenotypes and the met-QTL analysis.
BMI, body mass index (kg/m2); FEV1/FVC, post-bronchodilator forced expiratory volume at one second/forced vital capacity; FEV1pp, FEV1 percent predicted.
a
Mean and standard deviations provided.
COPD, chronic obstructive pulmonary disease.