Table 5.
Module variance explained by genetic and environmental variables
| Phenotype | Metabolite | Module ID | Module beta | Adjusted score | Most significant independent SNP | Consequence | Closest gene | Module first PC variance explained by genetic variants | Module first PC variance explained by covariates | Metabolite variance explained by genetic variants | Metabolite variance explained by covariates |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FEV1pp | 3-Amino-2-piperidone | 2 | −0.005 | 0.006 | rs37369 | Missense variant | AGXT2 | 0.8 | 10.8 | 18.9 | 4 |
| FEV1pp | (S)-a-Amino-omega-caprolactam | 2 | −0.005 | 0.006 | NA | NA | NA | 0.8 | 10.8 | NA | NA |
| FEV1pp | Tetradecadienedioate (C14:2-DC)* | 19 | −0.006 | 0.001 | rs11626972 | Upstream gene variant | ACOT2 | 13.2 | 3 | 5.5 | 2 |
| FEV1pp | Decadienedioic acid (C10:2-DC)** | 19 | −0.006 | 0.001 | rs58231493 | Upstream gene variant | ACOT2 | 13.2 | 3 | 18.6 | 3.2 |
| FEV1/FVC | 1-Methylnicotinamide | 3 | 0.734 | 0.029 | rs1495741 | Intergenic variant | NAT2 | 0.2 | 2.8 | 5.8 | 7 |
| FEV1/FVC | Nicotinamide | 3 | 0.734 | 0.029 | NA | NA | NA | 0.2 | 2.8 | NA | NA |
| FEV1/FVC | N1-methyl-2-pyridone-5-carboxamide | 3 | 0.734 | 0.029 | NA | NA | NA | 0.2 | 2.8 | NA | NA |
| FEV1/FVC | 2-Aminobutyrate | 4 | 1.031 | 0.002 | rs10168931 | Intron variant | NAT8 | 0.1 | 1.8 | 8.5 | 2.3 |
| FEV1/FVC | Gamma-glutamyl-2-aminobutyrate | 4 | 1.031 | 0.002 | NA | NA | NA | 0.1 | 1.8 | NA | NA |
| FEV1/FVC | Aspartate | 10 | 1.299 | 0 | rs750062 | Upstream gene variant | ASPG | 0.3 | 17 | 6.6 | 6.5 |
| FEV1/FVC | Glutamate | 10 | 1.299 | 0 | NA | NA | NA | 0.3 | 17 | NA | NA |
| FEV1/FVC | Linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2]* | 18 | 0.916 | 0.015 | NA | NA | NA | 3.8 | 4.6 | NA | NA |
| FEV1/FVC | Oleoyl-arachidonoyl-glycerol (18:1/20:4) [2]* | 18 | 0.916 | 0.015 | rs174567 | Intron variant | FADS2 | 3.8 | 4.6 | 5 | 3.1 |
ModuleID, module ID within phenotype; module beta, beta estimate of change in modules based on 1 unit increase in phenotype; adjusted score, score (p-value) after multiple testing correction; most significant independent SNP, SNP most significantly associated with metabolite. NA, no SNPs significantly associated; consequence, VEP annotation of variant; closest gene, closest gene to SNP as mapped in VEP; module first PC variance explained by genetic variants, adjusted r2 of linear regression model with the first PC of the module and independent mQTL SNPs. Module first PC variance explained by covariates, adjusted r2 of linear regression model with the first PC of the module and covariates (see Materials and Methods section). Metabolite variance explained by genetic variants, adjusted r2 of linear regression model with metabolite and independent mQTL SNPs. Metabolite variance explained by covariates, adjusted r2 of linear regression model with metabolite and covariates (see Materials and Methods section).
Indicates compounds that have not been officially confirmed based on a standard, but Metabolon is confident in its identity; **indicates a compound for which a standard is not available, but Metabolon is confident in its identity or the information provided; (#) or [#] indicates a compound that is a structural isomer of another compound in the Metabolon spectral library.
PC, principal component.