Table 3. Cox proportional hazard model of IRF family members and six types of tumor-infiltrating immune cells in LGG and GBM (TIMER).

Variable	LGG						GBM
	Coef	HR	95%CI_L	95%CI_U	P-value	Sig	Coef	HR	95%CI_L	95%CI_U	P-value	Sig
B_cell	10.843	51189.065	55.429	47273219.787	0.002	**	0.242	1.274	0.186	8.739	0.806
CD8_Tcell	7.374	1593.545	1.284	1977201.523	0.042	*	–0.127	0.881	0.236	3.283	0.850
CD4_Tcell	5.869	353.828	0.089	1399115.433	0.165		2.947	19.048	1.814	200.025	0.014	*
Macrophage	3.359	28.764	0.46	1792.334	0.111		0.540	1.715	0.137	21.455	0.675
Neutrophil	–6.858	0.001	0.000	1.749	0.070		–0.977	0.377	0.017	8.373	0.537
Dendritic	–2.367	0.094	0.002	5.295	0.250		2.005	7.426	2.131	25.882	0.002	**
IRF1	0.508	1.662	1.241	2.226	0.001	**	–0.536	0.585	0.389	0.881	0.010	*
IRF2	0.161	1.174	0.698	1.976	0.546		0.323	1.381	0.812	2.348	0.23
IRF3	0.160	1.173	0.752	1.829	0.481		–0.021	0.980	0.554	1.732	0.944
IRF4	–0.332	0.717	0.464	1.110	0.136		–0.059	0.943	0.298	2.978	0.920
IRF5	0.157	1.170	0.695	1.972	0.555		0.239	1.270	0.830	1.943	0.271
IRF6	–0.150	0.860	0.627	1.181	0.351		–0.301	0.740	0.491	1.115	0.150
IRF7	0.344	1.411	0.980	2.030	0.064		0.545	1.725	1.159	2.566	0.007	**
IRF8	–0.755	0.470	0.326	0.678	0.000	**	–0.521	0.594	0.373	0.944	0.028	*
IRF9	–0.379	0.685	0.441	1.063	0.092		–0.201	0.818	0.503	1.331	0.419

Note: ^*P < 0.05, ^**P <0.01