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Diagram depicting the signaling mechanisms of C2dat2 in CIRI. CIRI induces up-regulated C2dat2 to bind with HSC70/HSP90, blocks the RISC assembly, reduces the chaperone to load miR-30d-5p duplexes into Ago proteins, and inhibits the miR-30d-5p silencing of DDIT4 and then inhibits mTOR signaling pathway protein phosphorylation and facilitates neuronal autophagy and apoptosis.
