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. 2021 Apr 22;13(8):12007–12015. doi: 10.18632/aging.202905

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Copyright: © 2021 Yuan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Elevated expression of LINC00514 enhanced cell growth and EMT progression by sponging KRAS. (A) The level of KRAS was downregulated in HGC-27 cells after transfection with si-KRAS vectors. (B) The expression of KRAS was measured by qRT-PCR. (C) Downregulation of KRAS suppressed CDK2 expression in LINC00514-overexpressing HGC-27 cells. (D) Knockdown of KRAS inhibited cell growth in LINC00514-overexpressing HGC-27 cell. (E) The expression levels of E-cadherin, N-cadherin and vimentin were detected by qRT-PCR. *p<0.05, **p<0.01 and ***p<0.001.