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. 2021 Mar 26;13(8):11188–11206. doi: 10.18632/aging.202785

Figure 6.

Figure 6

Regulatory mechanism of MIAT in MI mice with the involvement of miR-10a-5p and EGR2. Inhibition of the MIAT induces miR-10a-5p-dependent inhibition of EGR2 and reduces the production of cleaved caspase-3, ultimately suppressing the apoptosis of cardiomyocytes.