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. 2021 Apr 4;13(8):11257–11280. doi: 10.18632/aging.202811

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Copyright: © 2021 Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Survival analysis of immune cells based on the TIMER database. Horizontal and vertical axes represent survival times and survival rates, respectively. Yellow and blue curves are samples with higher and lower immune cell fractions, respectively. (A–L) Lower infiltration levels of macrophages (B), dendritic cells (C), and neutrophil (D), CD4+ T cells (E), Tregs (H), Immature DC (I), Activated DC (K) and Activated CD4 (L) with improved survival outcomes, and higher infiltration levels of B cells (A), CD8+ T cells (F), MDSC (G) and Plasmocytoid DC (J) were associated with poor survival outcomes in HCC. HCC, hepatocellular carcinoma; TIMER, Tumor Immune Estimation Resource; Tregs, T cells regulatory; MDSC, myeloid-derived suppressor cells.