Table 1A. Subject demographics: cognitively normal participants.
| Tercile 1 (n=30) | Tercile 2 (n=29) | Tercile 3 (n=31) | p value | |
| Age at diagnosis (years) | 58.80 (6.44)b,c | 64.9 (6.61) | 65.6 (6.18) | p<0.001 |
| Sex (M/F), n | 17/13 | 17/12 | 16/15 | p = 0.852 |
| Education (years) | 13.30 (4.41) | 13.2 (2.92) | 12.6 (3.01) | p = 0.661 |
| MMSE | 28.8 (1.35) | 28.4 (1.76) | 28.7 (1.47) | p = 0.616 |
| MOCA | 28.2 (1.38) | 27.3 (2.31) | 27.7 (1.81) | p = 0.183 |
| WMH (cm3) | 0.92 (0.36)c | 2.27 (0.51)c | 8.03 (5.18) | p<0.001 |
| Total GMV (cm3) | 580.52 (40.7) | 581.38 (47.2) | 559.52 (63.4) | p = 0.179 |
| Average SBP (mmHg) | 126.59 (17.36) | 127.24 (14.89) | 136.07 (16.59) | p = 0.060 |
| Total lacunes | 0.20 (0.41) | 0.62 (0.97) | 1.26 (2.53) | p = 0.038 |
| Total microbleeds, n=38 | 0.36 (0.67) | 0.15 (0.55) | 0.64 (0.93) | p = 0.245 |
| APOE4 Carrier, n | 4/30 | 3/29 | 5/31 | p = 0.805 |
| ADAS Delayed recall z-score | 0.168 (0.98) | 0.166 (0.73) | -0.051 (0.99) | p = 0.566 |
| ADAS Immediate recall z-score | -0.364 (0.88) | -0.099 (0.85) | -0.208 (1.33) | p = 0.625 |
| Color Trails 2 z-score | 0.450 (0.608) | 0.437 (0.95) | 0.406 (1.78) | p = 0.99 |
| FAB z-score | 0.683 (0.41) | 0.589 (0.45) | 0.552 (0.59) | p = 0.568 |
Values represent mean (SD) unless otherwise indicated.
Superscript letters indicate whether group mean was significantly different compared with bTercile 2, cTercile 3, based on post-hoc comparisons (p < 0.05) following one-way analysis of variance. Chi-square tests were carried out on sex.
Abbreviations: MMSE, mini-mental state examination; MOCA, Montreal Cognitive Assessment; WMH, white matter hyperintensity; GMV, grey matter volume; SBP, systolic blood pressure; ADAS, Alzheimer’s disease assessment scale; FAB, frontal assessment battery.