Table 1B. Subject demographics – mild cognitive impairment.
| Tercile 1 (n=31) | Tercile 2 (n=30) | Tercile 3 (n=32) | p value | |
| Age at diagnosis (years) | 56.40 (6.78)b,c | 57.09 (6.38)c | 62.28 (6.75) | p<0.001 |
| Sex (M/F), n | 10/21 | 17/13 | 20/12 | p = 0.040 |
| Education (years) | 12.80 (3.15) | 13.63 (3.80) | 11.62 (3.84) | p = 0.094 |
| MMSE | 28.16 (1.44) | 27.30 (2.08) | 27.46 (1.52) | p = 0.115 |
| MOCA | 26.32 (2.65) | 24.96 (3.05) | 25.62 (2.82) | p = 0.183 |
| WMH (cm3) | 0.72 (0.39)b,c | 2.55 (0.87)c | 10.75 (8.01) | p<0.001 |
| Total GMV (cm3) | 590.85 (58.39) | 605.31 (59.90) | 575.05 (51.92) | p = 0.116 |
| Average SBP (mmHg) | 126.94 (18.34) | 131.09 (15.74) | 131.36 (16.32) | p = 0.514 |
| Total lacunes | 0.35 (0.66) | 0.4 (0.62) | 2.13 (2.43) | p<0.001 |
| Total microbleeds, n=68 | 0.16 (0.51) | 0.36 (0.64) | 1.54 (3.98) | 0.132 |
| APOE4 Carrier, n | 5/28 | 8/26 | 6/28 | p = 0.513 |
| ADAS Delayed recall z-score | 0.311 (1.11) | 1.17 (1.85) | 0.772 (0.99) | p = 0.056 |
| ADAS Immediate recall z-score | 0.435 (1.29) | 0.998 (1.59) | 0.848 (1.55) | p = 0.315 |
| Color Trails 2 z-score | -0.092 (0.97) | 0.127 (0.84) | -0.78 (3.49) | p = 0.27 |
| FAB z-score | 0.395 (0.68) | 0.371 (0.78) | 0.113 (1.10) | p = 0.38 |
Values represent mean (SD) unless otherwise indicated.
Superscript letters indicate whether group mean was significantly different compared with bTercile 2, cTercile 3, based on post-hoc comparisons (p < 0.05) following one-way analysis of variance.
Chi-square tests were carried out on sex.
Abbreviations: MMSE, mini-mental state examination; MOCA, Montreal Cognitive Assessment; WMH, white matter hyperintensity; GMV, grey matter volume; SBP, systolic blood pressure; ADAS, Alzheimer’s disease assessment scale; FAB, frontal assessment battery.