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. 2021 Apr 20;13(8):11752–11761. doi: 10.18632/aging.202869

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Copyright: © 2021 Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Zileuton improves neurological scores, BBB permeability and brain water content after SAH. (A–C) Effect of Zileuton with and without LY294002 on the indicated neurological functions (A); water content in the left and right cortical hemispheres (LH and RH, respectively), brain stem (BS) and cerebellum (CB) (B); and BBB permeability in the same brain regions, as indicated by Evans blue extravasation (C) (n = 6 in each group). ^*P < 0.05 vs sham group and ^&P < 0.05 vs SAH group, ^#P < 0.05 vs SAH + Zileuton group.