Figure 2: On-going and future applications of CRISPR technology for solid organ transplantation.
A) Applications of CRISPR-based technologies at cellular level for tolerance induction. B) CRISPR mediated research strategies. C) Xenotransplantation from CRISPRed transgenic animals and CRISPRed chimeric animal for solid organ. D) Potential ex-vivo CRISPR application for solid organs inside the pump. (ECD: Expanded Criteria Donor, SCNT: Somatic Cell Nuclear Transfer, HSC: hematopoietic stem cell, MSC: Mesenchymal Stem Cell).