. Author manuscript; available in PMC: 2021 May 10.

Published in final edited form as: Behav Res Ther. 2017 Oct 7;101:58–70. doi: 10.1016/j.brat.2017.09.012

Table 2.

ENGAGE project aims organized according to the self-regulation targets of focus, the assays used to assess each target and the settings in which the assays were undertaken.

Target	Assay settings	AIMS
		AIM 1: Target Engagement	AIM 2: Target Malleability	AIM 3: Target Prediction
		Includes evaluation of convergent validity	Includes evaluation of concurrent validity	Includes evaluation of predictive validity
Regulation of Emotion	Lab-based Virtual Reality Naturalistic	Activation on emotion fMRI tasks will correlate with emotion identification behavior and with self-reported emotion regulation.	Across timepoints, changes in emotion task fMRI activation will correlate with changes in self-reported emotion and behavior, VR, and smartphone sampling of mood-related word usage.	Emotion task baseline measures and assay changes over time will predict changes in health behaviors and outcomes.
Regulation of Cognition	Lab-based Virtual Reality Naturalistic	Activation on cognitive control fMRI tasks will correlate with scores of omissions/commissions on cognitive behavioral paradigms and self-report coping strategies.	Across timepoints, changes in cognitive task fMRI activation will correlate with changes in cognitive self-report, behavior, VR, and smartphone sampling of cognitive metrics.	Cognitive task baseline measures and assay changes over time will predict changes in health behaviors and outcomes.
Regulation of Self-Focused Reflection	Lab-based Virtual Reality Naturalistic	Resting state fMRI activation and connectivity will correlate with virtual reality mindfulness and self-reported reflection measures.	Across timepoints, changes in resting activation and connectivity will correlate with changes in reflection self-report, behavior, VR, and smartphone sampling.	Resting state baseline assays and assay changes over time will predict changes in health behaviors and outcomes.
Across all Targets	Across Settings	Within each target domain, lab-based assays will correlate with VR measures & naturalistic passive assays.	Changes in lab-based assays will correlate with changes in VR and naturalistic passive sampling assays within target domains (within subject).	Changes in lab-based assays will differentiate treatment responders and nonresponders. Treatment-related changes in Lab-based assays will correlate with those on Virtual Reality and Naturalistic assays.