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[Preprint]. 2021 May 4:2021.05.03.442357. [Version 1] doi: 10.1101/2021.05.03.442357

Figure 2. SARS-CoV-2 CMA3p20 induces disease restricted to the lung.

Figure 2.

a-f) Ten-week-old Balb/c mice were infected with 105 PFU of SARS-CoV-2 CMA3 (black) or CMA3p20 (blue) and followed for a) weight loss and viral titer in the b) lung, c) trachea, d) heart, e) brain, and f) blood. g-i) Histology from CMA3p20 infected mice showed g) viral antigen (N-protein) staining in the airways and parenchyma at day 2. Significant lung infiltration, inflammation and damage was observed at h) day 2 and i) day 4 post infection. Magnification at 10x for g-i.