. Author manuscript; available in PMC: 2021 Sep 1.

Published in final edited form as: Am J Reprod Immunol. 2020 Nov 4;85(3):e13358. doi: 10.1111/aji.13358

Table 2.

Immune cell subtypes that are differentially abundant between high and normal BMI groups.

Cell Subtype	Marker Expression Phenotype^‡	High BMI		Normal BMI		Fold-change^†	P-value

		Mean (%)	SD (%)	Mean (%)	SD (%)
Myeloid cell	CD68^midCD16^lowFas^low	0.09	0.09	0.29	0.19	3.22(−)	0.022
Myeloid cell	CD68⁺CD16⁺CD86⁺Fas⁺HLA-DR⁺CCR2⁺CCR5⁺	0.10	0.10	0.37	0.32	3.70(−)	0.044
Myeloid cell	CD68⁺CD45RA⁺HLA-DR⁺CCR2⁺CCR5⁺	0.07	0.08	0.59	0.47	8.43(−)	0.011
Myeloid cell	CD68^hiCD16⁻	0.06	0.04	0.61	0.73	10.17(−)	0.024
Myeloid cell	CD68^lowCD16⁻	0.20	0.21	0.69	0.67	3.45(−)	0.046
Natural killer cell	CD56⁺CD16^lowCD45RA⁺	0.22	0.30	0.74	0.56	3.36(−)	0.028
T helper cell	CD3⁺CD4⁺CD25^hiCD27^hi	0.44	0.26	0.22	0.10	2.00(+)	0.028
T helper cell	CD3⁺CD4⁺CD25^midCD27^hi	0.42	0.26	0.21	0.11	2.00(+)	0.027
T helper cell	CD3⁺CD4⁺CD27^midCD45RA^lowCCR7^mid	0.73	0.88	0.20	0.12	3.65(+)	0.02
T helper cell	CD3⁺CD4⁺CD27^hiCD45RA^low	0.26	0.18	0.10	0.06	2.60(+)	0.013
T helper cell	CD3⁺CD4⁺CD27^midCCR7^low	0.23	0.24	0.05	0.05	4.60(+)	0.005
T helper cell	CD3⁺CD4⁺CD27^midCCR7^mid	0.70	0.82	0.21	0.27	3.33(+)	0.036
T helper cell	CD3⁺CD4⁺CD16^midCD27^midCD68^midFas^midCCR7^hi	0.29	0.41	0.11	0.08	2.63(+)	0.043

^‡

All clusters are CD45⁺CD38⁺HLA-ABC⁺ in addition to the listed markers. P-values from multivariate linear regression model adjusting for maternal BMI and fetal sex.

^†

Positive and negative signs indicate higher or lower mean in the High BMI group, respectively.