Table 2.
Clinical features and laboratory data at admission
| All patients (n = 100) | IRS system | P | Post-hoc test* | |||
|---|---|---|---|---|---|---|
| Mild (n = 29) |
Moderate (n = 12) |
Severe (n = 59) |
||||
| Temperature, °C | 37.1 ± 0.9 | 37.1 ± 0.9 | 37.1 ± 1.0 | 37.1 ± 0.9 | 0.988 | |
| SaO2, % at room air | 79.5 ± 13.9 | 83.5 ± 9.8 | 77.3 ± 12.9 | 78.0 ± 15.4 | 0.182 | |
| Heart rate, beats/min | 97.4 ± 20.0 | 96.5 ± 16.1 | 109.1 ± 14.1 | 95.3 ± 22.1 | 0.063 | |
| Respiratory rate, breaths/min | 24.7 ± 6.2 | 22.5 ± 5.4 | 26.3 ± 7.9 | 25.4 ± 6.0 | 0.079 | |
| WBC × 103/μL, median (IQR) | 8.5 (6.0–11.6) | 6.9 (4.9–7.9) | 13.6 (11.1–14.9) | 8.9 (6.0–11.9) | < 0.0001 |
a: < 0.0001 b: 0.005 c: 0.004 |
| Neutrophils × 103/μL, median (IQR) | 7.5 (4.6–10.5) | 5.2 (3.6–6.9) | 12.0 (9.8–13.6) | 8.2 (5.4–10.7) | < 0.0001 |
a: < 0.0001 b: 0.001 c: 0.006 |
| Lymphocytes × 103/μL, median (IQR) | 0.7 (0.6–1.0) | 0.8 (0.6–1.1) | 0.9 (0.7–1.0) | 0.7 (0.5–0.9) | 0.971 | |
| Hemoglobin, g/dL, median (IQR) | 14.8 (13.6–16.0) | 15.5 (14.7–16.0) | 14.8 (13.9–16.1) | 14.5 (12.9–16.1) | 0.031 |
a: 0.415 b: 0.023 c: 0.850 |
| Platelets × 103/μL, median (IQR) | 204 (163–278) | 179 (150–230) | 228 (170–253) | 221 (175–292) | 0.463 | |
| LDH, U/L, median (IQR) | 345 (262–452) | 295 (209–401) | 410 (344–482) | 357 (269–497) | 0.056 | |
| D-dimer, ng/mL, median (IQR) | 377 (215–665) | 172 (116–443) | 288 (253–1913) | 516 (256–861) | 0.156 | |
| Ferritin, μg/L, median (IQR) | 640 (274–1120) | 438 (198–848) | 598 (247–1848) | 704 (351–1184) | 0.233 | |
| C-reactive protein, mg/L, median (IQR) | 149 (71–257) | 109 (37–154) | 195 (102–257) | 181 (81–302) | 0.004 |
a: 0.074 b: 0.005 c: 0.999 |
| Fibrinogen, mg/dL, median (IQR) | 5.5 (4.6–6.1) | 5.0 (4.3–5.7) | 6.1 (5.5–6.6) | 5.6 (4.6–6.2) | 0.003 |
a: 0.002 b: 0.463 c: 0.013 |
| Albumin, g/dL, median (IQR) | 3.4 (3.1–3.8) | 3.9 (3.7–4.0) | 3.8 (3.6–3.8) | 3.1 (2.9–3.4) | < 0.0001 |
a: 0.317 b: < 0.0001 c: < 0.0001 |
| Troponin I, ng/mL, median (IQR) | 11.6 (5.6–39.0) | 8.2 (4.5–18.5) | 10.5 (5.2–27.2) | 18.3 (6.6–63.2) | 0.501 | |
| Interleukin-6, pg/mL, median (IQR) | 14.2 (4.5–57.0) | 13.3 (4.5–52.1) | 15.6 (4.5–25.2) | 11.5 (4.5–65.4) | 0.529 | |
| Creatine kinase, U/L, median (IQR) | 72 (49–12) | 106 (48–187) | 67 (55–212) | 71 (48–226) | 0.749 | |
| Serum creatinine, mg/dL, median (IQR) | 1.0 (0.8–1.4) | 0.9 (0.8–1.1) | 0.9 (0.8–1.8) | 1.0 (0.8–1.5) | 0.504 | |
Data are presented as mean ± standard deviation unless otherwise specified. Significant P values are in bold
Definitions: IRS system, Inflammation-based risk scoring system; SaO2, oxygen saturation; WBC, white blood cells; IQR, interquartile range; LDH, lactate dehydrogenase
* a: Mild versus Moderate; b: Mild versus Severe; c: Moderate versus Severe