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. 2021 Apr 26;12:587518. doi: 10.3389/fendo.2021.587518

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Copyright © 2021 Fröhlich and Wahl

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Generation of biologically active thyroid hormone metabolites from thyroxine. Circles mark agonists and boxes antagonistically acting metabolites. 3,5-T2, 3,5-diiodothyronine; T1AM, 3-iodothyronamine; rT₃, reverse triiodothyronine; TA₄, tetraiodoacetic acid; T0AM, thyronamine; TA₃, triiodoacetic acid.