Table 1:
Baseline characteristics, laboratory values, and liver volume measurements in controls and patients with cirrhosis
| Variables | Controls (N=47) | Cirrhosis (N=556) | p-value |
|---|---|---|---|
| Age (Yrs) | 52.2±7.5 | 55.8±10.1 | 0.71 |
| Gender (Men, n %) | 23 (49%) | 339 (61%) | 0.10 |
| Race (Whites, n %) | 41 (87%) | 500 (89%) | 0.71 |
| Body weight (Kg) | 85.0±18.4 | 87.1±21.3 | 0.46 |
| Height (cm) | 170.5±12.2 | 170.7±13.0 | 0.92 |
| Body mass index (kg/m2) | 29.6±6.8 | 30.2±11.0 | 0.59 |
| White blood cell counts (×103/mm3) | 10.3±4.5 | 5.8±3.4 | <0.0001 |
| Hemoglobin (g/dl) | 13.6±1.8 | 12.5±5.9 | 0.002 |
| Platelet counts (×103/mm3) | 276.4±101.2 | 111.1±77.2 | <0.0001 |
| Blood urea nitrogen (mg/dl) | 13.4±5.8 | 15.0±12.5 | 0.10 |
| Creatinine (mg/dl) | 0.9±0.2 | 1.1±1.5 | 0.0001 |
| Total bilirubin (mg/dl) | 1.5±5.8 | 2.6±3.3 | 0.21 |
| Alanine aminotransferase (ALT, U/L) | 22.5±15.6 | 54.1±87.0 | <0.0001 |
| Aspartate aminotransferase (AST, U/L) | 20.7±10.7 | 78.0±108.7 | <0.0001 |
| Alkaline phosphatase (ALP, U/L) | 83.5±30.8 | 132.4±108.4 | <0.0001 |
| Albumin (g/dl) | 4.1±0.4 | 3.0±0.7 | <0.0001 |
| Total protein (g/dl) | 7.3±0.6 | 7.1±3.2 | 0.34 |
| International normalized ratio (INR) | 1.1±0.7 | 1.7±6.9 | 0.06 |
| MELD scores | N/A | 11.6±7.0 | <0.0001 |
| Total liver volume (TLV, cm3) | 1789.5±421.1 | 1639.8±594.5 | 0.02 |
| Functional liver volume (FLV, cm3) | 1728.4±413.4 | 1589.4±579.8 | 0.03 |
| Portal vein volume (PVV, cm3) | 33.5±18.8 | 29.1±29.7 | 0.15 |
| Segment 1 volume (cm3) | 40.2±20.6 | 46.0±47.9 | 0.11 |
| Segment 2 volume (cm3) | 214.9±78.7 | 257.7±189.8 | 0.002 |
| Segment 3 volume (cm3) | 124.1±80.6 | 184.0±139.5 | <0.0001 |
| Segment 4 volume (cm3) | 293.2±101.6 | 249.2±155.6 | 0.0006 |
| Segment 5 volume (cm3) | 296.0±118.5 | 230.3±140.9 | 0.0007 |
| Segment 6 volume (cm3) | 177.3±92.5 | 167.4±164.8 | 0.51 |
| Segment 7 volume (cm3) | 272.8±99.6 | 250.7±126.4 | 0.15 |
| Segment 8 volume (cm3) | 310.3±104.7 | 231.2±103.5 | <0.0001 |
| Total spleen volume (cm3) | 218.3±105.4 | 796.2±508.5 | <0.0001 |
| Functional spleen volume (cm3) | 214.0±102.0 | 771.4±493.6 | <0.0001 |
| Total liver to spleen ratio | 9.98±5.2 | 3.15±3.1 | <0.0001 |
| Functional liver to spleen ratio | 9.77±5.0 | 3.16±3.2 | <0.0001 |