Table 3:
Baseline characteristics, laboratory values, and liver and spleen volume measurements stratified by Child Pugh Classification.
| Variables | Compensated stage Child Class A (N=202) | Decompensated stage Child Class B and C (N=354) | p-value |
|---|---|---|---|
| Age (Yrs) | 56.4±10.4 | 55.5±9.9 | 0.35 |
| Body weight (Kg) | 85.4±19.2 | 88.0±22.3 | 0.14 |
| Height (cm) | 169.7±13.1 | 171.3±12.9 | 0.17 |
| Body mass index (kg/m2) | 29.4±6.3 | 30.6±12.9 | 0.11 |
| White blood cell counts (×103/mm3) | 5.6±3.5 | 5.8±3.2 | 0.37 |
| Hemoglobin (g/dl) | 13.4±6.2 | 12.0±7.0 | 0.001 |
| Platelet counts (×103/mm3) | 122.1±66.6 | 104.7±82.1 | 0.007 |
| Blood urea nitrogen (mg/dl) | 14.5±8.8 | 15.3±14.2 | 0.42 |
| Creatinine (mg/dl) | 1.2±1.5 | 1.1±1.4 | 0.25 |
| Total bilirubin (mg/dl) | 1.2±0.5 | 3.4±3.9 | <0.0001 |
| Alanine aminotransferase (ALT, U/L) | 48.4±44.7 | 57.3±103.8 | 0.16 |
| Aspartate aminotransferase (AST, U/L) | 55.2±45.2 | 91.1±130.4 | <0.001 |
| Alkaline phosphatase (ALP, U/L) | 110.9±70.7 | 145.0±123.7 | <0.0001 |
| Albumin (g/dl) | 3.6±0.5 | 2.7±0.5 | <0.0001 |
| Total protein (g/dl) | 7.6±5.2 | 6.8±0.9 | 0.02 |
| International normalized ratio (INR) | 1.2±0.1 | 1.9±0.45 | 0.06 |
| MELD scores | 8.4±5.0 | 13.4±7.3 | <0.0001 |
| Total liver volume (TLV, cm3) | 1754.0±562.3 | 1574.7±603.2 | 0.0005 |
| Functional liver volume (FLV, cm3) | 1676.9±573.4 | 1539.5±578.2 | 0.007 |
| Segment 1 volume (cm3) | 48.2±47.5 | 44.7±48.0 | 0.41 |
| Segment 2 volume (cm3) | 271.4±266.8 | 249.8±126.0 | 0.28 |
| Segment 3 volume (cm3) | 209.0±175.4 | 169.8±112.2 | 0.004 |
| Segment 4 volume (cm3) | 262.2±150.9 | 241.7±158.0 | 0.13 |
| Segment 5 volume (cm3) | 255.6±170.5 | 216.1±119.0 | 0.004 |
| Segment 6 volume (cm3) | 177.6±109.1 | 161.6±189.8 | 0.20 |
| Segment 7 volume (cm3) | 263.7±112.8 | 243.4±133.0 | 0.058 |
| Segment 8 volume (cm3) | 242.7±100.0 | 224.5±105.0 | 0.04 |
| Total volume:body weight (cm3:kg) | 21.1±7.1 | 18.7±9.3 | 0.0009 |
| functional volume:body weight (cm3:kg) | 20.2±7.1 | 18.3±8.9 | 0.007 |
| Segment 1:BW (cm3/kg) | 0.6±0.6 | 0.5±0.5 | 0.26 |
| Segment 2:BW (cm3/kg) | 3.2±2.5 | 2.9±1.9 | 0.33 |
| Segment 3:BW (cm3/kg) | 2.5±2.1 | 2.1±1.7 | 0.008 |
| Segment 4:BW (cm3/kg) | 3.2±1.9 | 2.8±2.1 | 0.07 |
| Segment 5:BW (cm3/kg) | 3.1±2.0 | 2.6±1.6 | 0.003 |
| Segment 6:BW (cm3/kg) | 2.1±1.3 | 1.9±2.0 | 0.11 |
| Segment 7:BW (cm3/kg) | 3.2±1.5 | 2.9±1.7 | 0.03 |
| Segment 8:BW (cm3/kg) | 2.0±1.2 | 2.6±1.3 | 0.02 |
| Total spleen volume (cm3) | 676.0±440.7 | 864.8±531.9 | <0.0001 |
| Functional spleen volume (cm3) | 655.3±427.8 | 837.6±516.5 | <0.0001 |
| Total spleen volume:BW (cm3/kg) | 7.9±5.0 | 10.3±7.6 | <0.0001 |
| Functional spleen volume:BW (cm3/kg) | 7.6±4.9 | 9.9±7.3 | <0.0001 |
| Total liver to spleen ratio | 4.0±2.9 | 2.7±3.2 | <0.0001 |
| Functional liver to spleen ratio | 3.9±2.8 | 2.7±3.2 | <0.0001 |