Table 4.
Effects of fish oil supplementation on subcortical and whole-brain tissue volumesa
| Week 0 | Week 18 | Change | Between groups | ||
|---|---|---|---|---|---|
| Amygdala | |||||
| Fish oil | 2150.71 (433.06) | 2162.68 (418.64) | 11.97 (267.24) | 0.03 (−0.33 to 0.39) | −0.01 (−0.26 to 0.24) |
| Placebo | 2174.94 (450.88) | 2189.54 (466.41) | 14.60 (263.34) | 0.03 (−0.32 to 0.38) | |
| Caudate | |||||
| Fish oil | 6779.88 (731.30) | 6806.83 (782.98) | 26.95 (297.59) | 0.04 (−0.32 to 0.39) | 0.04 (−0.21 to 0.29) |
| Placebo | 6844.56 (820.19) | 6861.15 (804.40) | 16.59 (209.17) | 0.02 (−0.33 to 0.37) | |
| Globus pallidus | |||||
| Fish oil | 3262.02 (335.64) | 3259.96 (362.09) | −2.07 (117.06) | −0.01 (−0.36 to 0.35) | 0.02 (−0.23 to 0.27) |
| Placebo | 3240.98 (289.25) | 3236.89 (324.39) | −4.09 (111.67) | −0.01 (−0.37 to 0.34) | |
| Hippocampus | |||||
| Fish oil | 7381.25 (859.94) | 7398.37 (847.26) | 17.12 (269.55) | 0.02 (−0.34 to 0.38) | −0.03 (−0.28 to 0.23) |
| Placebo | 7484.92 (879.23) | 7508.81 (784.38) | 23.88 (251.32) | 0.03 (−0.32 to 0.38) | |
| Nucleus accumbens | |||||
| Fish oil | 873.48 (209.40) | 870.70 (221.20) | −2.78 (120.58) | −0.01 (−0.37 to 0.34) | 0.14 (−0.11 to 0.39) |
| Placebo | 870.87 (179.13) | 851.41 (162.38) | −19.46 (112.53) | −0.11 (−0.47 to 0.24) | |
| Total gay matter | |||||
| Fish oil | 594 081.84 (54561.47) | 591311.60 (55633.34) | −2770.25 (9491.80) | −0.05 (−0.41 to 0.31) | −0.02 (−0.27 to 0.23) |
| Placebo | 607 242.96 (51775.85) | 604 666.41 (50 650.98) | −2576.54 (9626.18) | −0.05 (−0.40 to 0.30) | |
| Total white matter | |||||
| Fish oil | 540 831.42 (60158.67) | 542 851.52 (59 887.33) | 2020.10 (12 350.40) | 0.03 (−0.32 to 0.39) | 0.10 (−0.16 to 0.35) |
| Placebo | 544 596.68 (49 800.44) | 545 547.12 (49 323.68) | 950.45 (9854.20) | 0.02 (−0.33 to 0.37) |
a
All tissue volumes (mm3) are presented in raw units, unadjusted for intracranial volume. No comparisons between groups over time reached statistical significance in repeated measures MANOVAs with and without covariate control for intracranial volume. Fish oil n = 60, placebo n = 62, total N = 122.