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. Author manuscript; available in PMC: 2022 Mar 4.
Published in final edited form as: Cell. 2021 Feb 25;184(5):1348–1361.e22. doi: 10.1016/j.cell.2021.01.049

Figure 7. Schematic summarizing the relationship between HSC proliferation and clonal hematopoiesis.

Figure 7.

Factors that instigate HSC proliferation - for example the atherosclerosis trait complex, smoking, chronic psychosocial stress, heart failure or myocardial infarction - promote accelerated somatic evolution and CH emergence.