Table III.
Relationship of Changes Observed Over 12 Months to Attained Mean Arterial Pressure Control (MAP ≤100 vs. >100)
| MAP ≤100 mm Hg (n=8) | MAP > 100 mm Hg (n=9) | |||||
|---|---|---|---|---|---|---|
| Baseline | 12 Months | p Value | Baseline | 12 Months | p Value | |
| Glycohemoglobin A1c (%) | 9.9±0.6 | 8.4±0.7 | 0.0811 | 9.0±0.5 | 8.0±0.4 | 0.0384 |
| AGE (n=7,5) (IU) | 7.7±1.2 | 6.3±1.8 | 0.4043 | 15.6±3.2 | 8.1±1.5 | 0.0366 |
| Serum creatinine (mg/dL) | 1.5±0.2 | 1.5±0.2 | 0.8088 | 1.9±0.2 | 2.3±0.3 | 0.0156 |
| Creatinine clearance (mg/min) | 66±7 | 68±9 | 0.5073 | 53±6 | 42±7 | 0.0757 |
| Hemoglobin (g/dL) | 13.9±0.6 | 13.2±0.6 | 0.0790 | 13.4±0.6 | 11.7±0.6 | 0.0008 |
| Hematocrit (%) | 40.8±1.8 | 39.2±1.5 | 0.1480 | 38.9±1.9 | 35.0±1.7 | 0.0018 |
| Weight (kg) | 75.2±3.8 | 74.6±4.5 | 0.6048 | 71.4±2.9 | 72.4±3.7 | 0.6015 |
| Mean arterial pressure (mm Hg) | 93±3 | 94±2 | 0.6578 | 105±2 | 106±0.02 | 0.7955 |
| Systolic BP (mm Hg) | 129±4 | 133±2 | 0.2311 | 146±3 | 146±3 | 0.9464 |
| Diastolic BP (mm Hg) | 75±2 | 79±2 | 0.1588 | 86±2 | 84±1 | 0.3620 |
| D/NMAP (n=8,7) | 0.98±0.04 | 1.03±0.05 | 0.5413 | 1.02±0.03 | 1.06±0.02 | 0.2190 |
| LV mass (g) | 205±11 | 188±18 | 0.3435 | 208±24 | 188±21 | 0.1681 |
| LV septal thickness (mm) | 10.6±0.4 | 9.8±0.6 | 0.1108 | 9.9±0.5 | 9.7±0.5 | 0.6224 |
| E/A ratio | 1.32±0.19 | 1.52±0.19 | 0.0252 | 1.20±0.10 | 1.12±0.11 | 0.2414 |
| Fractional shortening (%) | 39±2 | 42±2 | 0.1888 | 39±2 | 37±2 | 0.5717 |
| Ejection fraction (%) | 61.2±1.2 | 61.9±1.3 | 0.7318 | 59.4±3.8 | 58.9±3.7 | 0.5943 |
| AGE=advanced glycated end products; BP=blood pressure; D/NMAP=diastolic/nonsignificant mean arterial pressure; LV=left ventricular; E/A=early‐to‐late diastolic filling | ||||||