Table III.

Studies on the Association Between Serum Uric Acid (SUA) and Target Organ Damage (TOD)

Study	Population (M/W)	Age (yr)*	TOD	Correlation Between SUA and TOD	Independent Role of SUA
Persky et al. 32	24,997 subjects	18–64	ECG abnormalities	Yes	Yes (W)
Mazza et al. Metabolism. 2000	130 T2DM patients (60/70)	53	Carotid abnormalities	Yes	Yes (W)
Bo et al. Eur J Clin Invest. 2001	1186 T2DM patients (628/558)	65	1) Microalbuminuria by UAE 2) Macroalbuminuria by UAE	Yes	1) No 2) Yes
Tuttle et al. 33	277 patients admitted for elective coronary angiography (195/82)	62	Angiographically defined coronary artery disease severity	Yes (W)	No
Ishizaka et al. 34	8141 general population (5470/2671)	57	1) Carotid plaque 2) Carotid IMT	Yes	1) Yes (M without MS) 2) No
Kawamoto et al. Intern Med. 2005	919 elderly persons (398/521)	75	Carotid IMT	Yes	Yes
Tsioufis et al. 35	842 patients with HTN (406/436)	53	1) LVH (echo) 2) Microalbuminuria by UAE	1) No 2) Yes	1) No 2) Yes
Viazzi et al. 36	425 patients with HTN (265/160)	47	1) LVH (echo) 2) Carotid abnormalities 3) Microalbuminuria by ACR	1) Yes (W) 2) Yes (W) 3) No	1) Yes (W) 2) Yes (W) 3) No
Tseng Kidney Int. 2005	343 patients with T2DM (144/199)	63	Albuminuria by ACR	Yes	Yes (patients without HTN)
Wu et al. 37	1005 IgA nephropathy	31	Arterial‐arteriolar lesions (light microscopy semiquantitative scoring)	Yes	Yes
Myllymaki et al. 38	202 patients with IgA nephropathy	41	Tubular atrophy (light microscopy semiquantitative scoring)	Yes	Yes
Iribarren et al. 39	11,488 subjects free of cardiovascular disease (4966/6522)	45–64	Carotid abnormalities	Yes (W, white M)	No
M=men; W=women; ECG=electrocardiographic; T2DM=type 2 diabetes mellitus; UAE=urinary albumin excretion; IMT=intima‐media thickness;MS=metabolic syndrome; HTN=hypertension; LVH (echo)=left ventricular hypertrophy assessed by echocardiogram; ACR=albumin/creatinine ratio; *expressed as mean or range