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Inhibition of hFXIa variants by 19S.a
| Mutant | IC50 (μM) | ΔY (%) |
|---|---|---|
| FXIaWT | 20.0±0.8b | 93±3 |
| FXIaA3 | 14.0±0.4 | 99±2 |
| FXIaCD | 34.0±1.5 | 96±3 |
| FXIaCD&A3 | 32.0±1.0 | 105±3 |
The IC50 and ΔY were calculated following nonlinear regression analysis of direct inhibition of hFXIa mutants (see Methods). Inhibition was monitored by spectrophotometric measurements of residual hFXIa activity.
Errors represent ±1 SE.
