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The Antihypertensive and Lipid‐Lowering Treatment to Prevent Heart Attack Trial: relative risk for stroke and combined cardiovascular disease (amlodipine vs. chlorthalidone and lisinopril vs. chlorthalidone). Data shown represent relative risk compared with chlorthalidone; *p=0.01 for interaction; CI=confidence interval Adapted with permission from JAMA. 2002;288:2981–2997.24
