Table III.
Double‐Blind Treatment Group* | |||||
---|---|---|---|---|---|
Lipid Parameter | AML 5 mg+ ATV 10 mg | AML 5 mg | ATV 10 mg | Placebo | Single‐Blind, Open‐Label** |
LDL‐C | −37.2±0.9†,†† | −1.8±0.9 | −33.9±0.9‡ | 0.2±0.8 | −41.0±0.4 |
Patients (n) | 201 | 193 | 193 | 229 | 687 |
Total cholesterol | −27.7±0.6‡‡†† | −2.1±0.6 | −24.4±0.6‡ | −0.9±0.6 | −31.0±0.4 |
Patients (n) | 201 | 193 | 193 | 229 | 687 |
Triglycerides | −23.0*±2.2†† | −2.3±2.3 | −17.2±23‡ | −0.1±2.1 | −29.0±1.1 |
Patients (n) | 201 | 193 | 193 | 229 | 687 |
HDL‐C | 5.0±1.0†† | 0.0±1.0 | 4.1±1.0§ | 0.2±0.9 | 5.2±0.6 |
Patients (n) | 201 | 193 | 193 | 229 | 687 |
Apolipoprotein B | −30.7±0.8§§†† | −1.7±0.8 | −27.9±0.8‡ | −1.0±0.7 | −34.5±0.4 |
Patients (n) | 189 | 185 | 183 | 210 | 687 |
LDL‐C=low‐density lipoprotein cholesterol; HDL‐C=high‐density lipoprotein cholesterol; *from baseline to the end of the doubleblind phase (Week 8); **from baseline to the end of the open‐label phase (Week 28); † p=0.007 vs. atorvastatin alone; †† p<0.001 vs. amlodipine alone; ‡ p<0.001 vs. placebo; ‡‡ p<.001 vs. atorvastatin alone; § p=0.005 vs. placebo; §§ p=0.013 vs. atorvastatin alone |