Table II.

Pharmacokinetics of Verapamil

Absorption, %	>90
Bioavailability, %	10–20
Protein binding, %
R‐isomer	94
S‐isomer	88
Volume of distribution, L/kg	3.8
Elimination half‐life, h
Acute	2–6
Chronic	8–12
Clearance, L/h/kg	0.51–1
Active metabolite	Norverapamil
Therapeutic plasma concentrations, ng/mL	80–300
Adapted from Weir and Zachariah. ⁴²