Table III.
Novel Drug Delivery Systems for Calcium Antagonists
| Generic Name | Brand Name | Dosing Interval | Delivery System |
|---|---|---|---|
| Diltiazem | Cardizem SR* | bid | Coated beads (multiple) |
| Cardizem CD* | qd | Coated beads (2 populations) | |
| Cardizem LA* | qd hs | Coated beads (multiple) | |
| Tiazac* | qd | Coated beads (multiple) | |
| Dilacor† | qd | Geomatrix | |
| Felodipine | Plendil‡ | qd | Coat core |
| Isradipine | DynaCirc CR§ | qd | Osmotic pump |
| Nicardipine | Cardene SR|| | bid | Coated beads and powder |
| Nifedipine | Procardia XL¶ | qd | Osmotic pump |
| Adalat CC# | qd | Coat core | |
| Nisoldipine | Sular** | qd | Coat core |
| Verapamil | Calan SR¶ | qd‐bid | Sodium alginate matrix |
| Isoptin SR†† | qd‐bid | Sodium alginate matrix | |
| Verelan‡‡ | qd | Coated beads (multiple) | |
| Covera‐HS¶ | qd hs | Osmotic pump with delay coat | |
| Verelan PM‡‡ | qd hs | Multiple beads with delay coat | |
| SR indicates sustained release; CD, controlled delivery; and CR, controlled release. *Biovail Pharmaceuticals, Inc, Bridgewater, NJ. †Watson Pharmaceuticals, Inc, Corona, CA. ‡AstraZeneca LP, Wilmington, DE. §Reliant Pharmaceuticals, Inc, Liberty Corner, NJ. ||Roche Laboratories Inc, Nutley, NJ. ¶Pfizer Inc, New York, NY. #Bayer Pharmaceuticals Corporation, West Haven, CT. **First Horizon Pharmaceutical Corporation, Alpharetta, GA. ††Abbott Laboratories, Abbott Park, IL. ‡‡ Elan Corporation, plc, Gainesville, GA. Adapted with permission from Prisant. 41 | |||