Table II.
Studies on the Effects of Statins on BP Level Using Ambulatory Measurements
Study | Patient Condition | No. of Patients | Regimens Compared | Duration | Mean Effect on SBP/DBP vs Baseline in the Statin Groups, mm Hg | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Abetel et al 40 | Hypercholesterolemia, hypertension | 23 | 40 mg Flu | 12 wk | −6.0a/−5.0a | ||||||
Magen et al 41 | Hypercholesterolemia, hypertension | 48 | 20 mg Ator vs vitamin C vs placebo | 8 wk | −13.7a/−7.8a | ||||||
Kanbay et al 42 | Hypercholesterolemia, hypertension | 50 | 20 mg Ator vs diet | 8 wk | −5.1a/‐5.2a | ||||||
Terzoli et al 43 | Hypercholesterolemia, hypertension, or normotension | 74 | 10–20 mg Pra or 10–20 mg Sim or 5–10 mg Ator vs Lec | 8 wk | −5.7a/−3.5a,b−0.7/−1c | Abbreviations: BP, blood pressure; SBP, systolic BP; DBP, diastolic BP; Flu, fluvastatin; Ator, atorvastatin; Pra, pravastatin; Sim, simvastatin; Lec, soy lecithin. aSignificant change vs baseline levels or the other group compared. bBP change in the group of hypertensives. cBP change in the group of normotensives. |