Table 1.
Characteristics of Studies Included in the Systematic Review
| Author (reference) | Year | Country | Age group | Etiology of hypothyroidism | Degree of hypothyroidism | Outcomes | Follow-up time (months) |
|---|---|---|---|---|---|---|---|
| Wasniewska et al. (36) | 2012 | Italy | Children Adolescents |
Idiopathic | Subclinical | Clinical symptoms Thyroid hormone status categorical Thyroid hormone status numerical |
3 |
| Battelino et al. (25) | 1994 | Slovenia | Children Adolescents |
Autoimmune | Mixed | Thyroid hormone status categorical | 0.33 |
| Radetti et al. (26) | 2017 | Italy | Children Adolescents |
Autoimmune | Mixed | Thyroid hormone status categorical Thyroid hormone status numerical |
12 2, 6, 12, 24 |
| Sklar (37) | 1986 | United States | Children Adolescents |
Autoimmune | Euthyroid Subclinical Overt |
Thyroid hormone status categorical | Variable (28–36) |
| Fava et al. (38) | 2009 | Italy | Children Adolescents Adults |
Autoimmune | Subclinical | Thyroid hormone status categorical | 1.3 |
| Takasu et al. (35) | 1992 | Japan | Children Adolescents Adults |
Autoimmune | Overt | Clinical symptoms Thyroid hormone status categorical |
12 |
| Takasu et al. (39) | 1990 | Japan | Adolescents Adults |
Autoimmune | Overt | Thyroid hormone status categorical | 3 |
| Carlwe et al. (40) | 2013 | Sweden | Adults | No description | Overt | Thyroid hormone status numerical | 0.25 |
| Rizzolo et al. (41) | 1986 | United States | Adults | No description | No description | Thyroid hormone status categorical | 0.75 |
| Krugman et al. (29) | 1975 | United States | Adults | Mixed | No description | Thyroid hormone status categorical | 2 |
| Rosario and Calsolari (27) | 2016 | Brazil | Adults | Mixed | Subclinical | Thyroid hormone status categorical Thyroid hormone status numerical |
24–120 Median: 60 |
| Ohsawa et al. (30) | 1981 | Japan | Adults | Autoimmune | No description | Thyroid hormone status categorical Thyroid hormone status numerical |
2 |
| Comtois et al. (32) | 1995 | Canada | Adults | Autoimmune | Mixed | Clinical symptoms Thyroid hormone status categorical Thyroid hormone status numerical |
0.75 |
| Höfling et al. (31) | 2013 | Brazil | Adults | Autoimmune | Overt | Thyroid hormone status categorical Thyroid hormone status numerical |
9 1 |
| Rieu et al. (33) | 1995 | France | Adults | Autoimmune | Euthyroid Hypothyroid |
Thyroid hormone status categorical | 2 |
| Livadas et al. (24) | 2018 | Greece | Adults | Other (mixed) | No description | Clinical symptoms Thyroid hormone status categorical Thyroid hormone status numerical |
1.5–2 |
| Nikolai (34) | 1989 | United States | Adults | Primary | Overt | Thyroid hormone status categorical |
6 12 36 |