Table 3.
Percent of Euthyroid Patients After Thyroid Hormone Discontinuation by Prior Indication for Therapy
| Population | Study | Indication for treatment | n | % Euthyroid |
|---|---|---|---|---|
| Children and adolescents | Battelino et al. (25) | Autoimmune hypothyroidism (overt or subclinical) | 29 | 3.5 |
| Wasniewska et al. (36) | Idiopathic SCH | 69 | 60.9 | |
| Radetti et al. (26) | Autoimmune hypothyroidism (overt or subclinical) | 140 | 55.7 | |
| Sklar (37) | Autoimmune euthyroid | 7 | 86 | |
| Autoimmune SCH | 4 | 65 | ||
| Autoimmune OH | 5 | 20 | ||
| Children, adolescents, and adults | Fava et al. (38) | Autoimmune hypothyroidism (overt or subclinical) | 14 | 21.4 |
| Takasu et al. (39) | Autoimmune OH | 92 | 23.9 | |
| Takasu et al. (35) | Autoimmune OH | 21 | 28.6 | |
| Adults | Rizzolo et al. (41) | Hypothyroidism: clinical diagnosis without adequate laboratory confirmation | 7 | 86 |
| Hypothyroidism: diagnosis based on laboratory tests | 7 | 14 | ||
| Hypothyroidism: diagnosis based on symptoms and the presence of goiter | 8 | 50 | ||
| Comtois et al. (32) | Autoimmune hypothyroidism (overt or subclinical) | 79 | 11 | |
| Krugman et al. (29) | OH | 10 | 70 | |
| Goiter | 1 | 100 | ||
| Hashimoto's thyroiditis | 2 | 100 | ||
| Nontoxic nodular goiter | 1 | 100 | ||
| Rieu et al. (33) | Euthyroid Goitrous Hashimoto's disease | 9 | 100 | |
| Autoimmune OH | 11 | 0 | ||
| Ohsawa et al. (30) | Euthyroid Hashimoto's thyroiditis | 13 11 |
69 55a |
|
| Livadas et al. (24) | Presence of thyroid nodules but not on suppression therapy | 96 | 63.5b | |
| Unknown reason for LT4 supplementation or no evidence of past thyroid dysfunction provided | 78 | 46.2b | ||
| Therapy initiated postpregnancy without reassessment | 15 | 73.3b | ||
| Hashimoto's thyroiditis or hypothyroidism-like or related symptoms | 102 | 67.6b | ||
| Nikolai (34) | OH | 49 | 0 | |
| Höfling et al. (31) | Autoimmune OH | 20 | 0 | |
| Rosario and Calsolari (27) | SCH with presence of TPO Ab with or without goiter, symptoms of hypothyroidism, dyslipidemia, depression, infertility, or unknown reasons | 182 | 23 |
a
% euthyroid after liothyronine discontinuation.
b
% hypothyroid (overt/subclinical) was reported for subgroups, and % euthyroid was derived from this report.
OH, overt hypothyroidism; SCH, subclinical hypothyroidism.