Table I.

Eligibility Criteria

Inclusion

Age at least 21 years

Average blood pressure 135–179 mm Hg systolic or 85–109 mm Hg diastolic for patients with diabetes, otherwise 145–179 mm Hg systolic or 95–109 mm Hg diastolic

Taking 0–3 antihypertensive medications

No change in medication regimen in the past 4 weeks

Exclusion

Clinic blood pressure ≥180 mm Hg systolic or ≥110 mm Hg diastolic

Evidence of hypertensive emergency

Myocardial infarction in the past 6 months

New York Heart Association class III or IV heart failure

Unstable angina

Serious renal or hepatic disease

Pregnancy

Life expectancy shorter than 3 years

Dementia or other cognitive impairment