Table II.
Impact of Dosing Time of Antihypertensive Therapies on Ambulatory BP
| Parameter | All Morning Drugs | One Drug at Bedtime | P |
|---|---|---|---|
| No. of patients | 260 | 318 | |
| Duration of sleep, h | 9 | 9 | .55 |
| 24‐Hour BP, mm Hg | 138/80 | 134/79 | .003/.011 |
| Daytime BP, mm Hg | 139/83 | 37/82 | .049/.205 |
| Nighttime BP, mm Hg | 134/75 | 128/72 | <.001/.001 |
| Day/night ratio for SBP, % | 4.1 | 6.3 | <.001 |
| Day/night ratio for DBP, % | 9.2 | 11.9 | <.001 |
| Day/night ratio indicates the percentage decline in blood pressure (BP) during nighttime BP relative to daytime BP (index of dipping). Adapted from Hermida et al. 11 | |||