Table II.

Change in Daytime and Nighttime Ambulatory SBP Level

Variable	No.	Darusentan	No.	Placebo
Baseline
Mean daytime SBP, mm Hg	76	139.3±1.6	39	141.3±2.2
Mean nighttime SBP, mm Hg	75	127.6±1.6	39	131.9±3.2
Mean daytime‐nighttime SBP ratio	75	7.8±0.9	39	6.9±1.2
Week 10 (300‐mg dose)
Mean daytime SBP, mm Hg	64	129.5±1.6	33	139.3±2.3
Mean nighttime SBP, mm Hg	63	117.1±1.8	31	129.6±2.7
Mean daytime‐nighttime SBP ratio	63	9.5±1.0a	31	6.7±1.1
Mean change from baseline to week 10
Daytime SBP, mm Hg	64	−10.6±1.4b	33	−2.2±2.3
Nighttime SBP, mm Hg	62	−11.9±1.6b	31	−3.3±2.6
Data are means ± SE. Mean daytime systolic blood pressure (SBP) was defined as the average ambulatory SBP level between 6 pm and 10 pm. Mean nighttime SBP was defined as the average ambulatory SBP level between 10 pm and 6 am. Daytime‐nighttime SBP ratio was calculated as the difference between mean daytime SBP level and mean nighttime SBP level divided by mean daytime SBP level and was expressed as a percentage. a P=.057 unadjusted for multiple comparisons. b P<.001 unadjusted for multiple comparisons.