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. 2021 Apr 26;12:659215. doi: 10.3389/fphar.2021.659215

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Copyright © 2021 Zhao, Wang, Yan, Zhou, Huang, Zhu, Ye, Zhang, Chen, Chen and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BSP promotes wound healing in DM mice. DM mice received BSP treatment for 12 days. Body weight (A) and fasting blood glucose (FBG) (B) were measured at day (d) 0, 6, and 12. Wound images of mice grouped in either normal control, DM plus vehicle or DM plus BSP were captured at days 0, 2, 4, 6, 8, 10, and 12 (C). Wound closure was expressed as the percentage of closed wound area (D). Mice were sacrificed and the levels of serum TNF-α and IL-1β were measured (E). Scale bar = 6 mm. *p < 0.05, **p < 0.01 vs. Normal controls; ^#p < 0.05 vs. DM + Vehicle. Values are means ± SEM (n = 6).