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. 2021 May 6;14:1827–1844. doi: 10.2147/JIR.S300679

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© 2021 Wasyluk and Zwolak.

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Nicotinamide adenine dinucleotide (NAD⁺) and poly (ADP-ribose) polymerase (PARP) inhibitors. (A) shows the substrate of the PARP family enzymes – NAD⁺. (B–F) show the PARP inhibitors mentioned in this review: nicotinamide (B), 3-aminobenzamide (C), PJ34 (D), and INO-1001 (E), olaparib (F). These contain motifs that mimic the nicotinamide component of NAD⁺ and bind to the catalytic site of PARP. Nicotinamide itself is also a natural inhibitor of this enzyme.