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. 2021 May 11;120(14):2859–2871. doi: 10.1016/j.bpj.2021.02.049

Figure 3.

Figure 3

Logos of designed sequences. (a) Sequence composition of the flattened apo CoV-2 state. (b) Sequence composition of the CoV-2 complex, using the flattening biases. Large letters signify residue types encountered in sequences of better affinity for hACE2, relative to the CoV-2 sequence LQSN. All 20 natural amino acids except P and G were considered at the first 4 positions (see Materials and methods). At position 501, bulky chemical types F, Y, W and H were also excluded. To see this figure in color, go online.