(a) Top 20 affinity sequences. (b) Top sequences, grouped by similarity with the CoV-2 sequence LQSN. (c) Sequence composition of various coronaviruses at designed positions 455, 493, 494, and 501 (SARS-CoV-2 numbering) (16,53). The residues are colored according to their physicochemical properties following the Zappo color scheme from Jalview (54). To see this figure in color, go online.